Mendon Road is the stretch of State Route 64 that runs through the town of Pittsford in Monroe County, New York, from the Thruway crossing at the Mendon town line north toward the village of Pittsford. South of the village it meets South Main Street, Stone Road and Mendon Center Road at a sharp angle, and the route finishes on South Main Street at Jefferson Road. The road's Mendon-to-Pittsford segment carried NY 15 in the 1920s before becoming NY 64 in 1930. Pittsford Mendon High School, at 472 Mendon Road, takes its name from the road.