Clarence is a town in northeastern Erie County, New York, northeast of Buffalo, with a population of 32,950 at the 2020 census. Established in 1808, it was the first town in Erie County, and Buffalo, Newstead, Alden and Lancaster were later formed from parts of it. The town is named for Prince William, Duke of Clarence, who later became King William IV. It has no incorporated villages; its communities include Clarence Hollow in the southeast, where settler Asa Ransom arrived in 1799, and Clarence Center, home to the town offices, with Tonawanda Creek forming the northern border and Main Street running across the south of town.